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Text Search
Text Search: Enter text or identifiers to search against iProClass for individual proteins, or PIRSF for protein families. An advanced search option is available for restriction of search terms, options, matching, and operators.

Batch Retrieval: Retrieve multiple entries from iProClass or multiple families from PIRSF database using a specific identifier, or a combination of different identifiers.
Sequence Search
BLAST/FASTA Search: Retrieve entries similar to your query using the BLAST or FASTA program. Two UniProt databases are available to perform the search: (1) UniProtKB, which contains functional information on proteins, with accurate, consistent, and rich annotation; or (2) UniRef100, which combines identical sequences and sub-fragments, from any organism, into a single entry.
A line summary containing sequence similarity results will be displayed. In addition, SSearch results will be shown along with the BLAST output.

Peptide Match: Find an exact match for a peptide sequence (3 to 30 amino acid long). Two UniProt databases can be used to perform the search: (1) UniProtKB, which contains functional information on proteins, with accurate, consistent, and rich annotation; or (2) UniRef100, which combines identical sequences and sub-fragments, from any organism, into a single entry.

Pattern Search: (1) Find proteins matching a user-defined or a PROSITE pattern in the UniProtKB database; or (2) Look for PROSITE patterns present in a query sequence.
Sequence Alignment
Multiple Alignment: Enter multiple sequences in FASTA format and/or multiple UniProtKB identifiers in the ID box to get the CLUSTALW alignment of the sequences along with a neighbor-joining tree and a PIR interactive tree and alignment viewer.

Pairwise Alignment: Insert two sequences using the single letter amino acid code or enter two UniProtKB identifiers. The results show the SSearch Smith-Waterman full-length alignments between the two sequences.
Others
PIRSF Scan: See if your protein belongs to a fully curated PIRSF by running PIRSF scan. This procedure may help in predicting protein function, and in getting more accurate information about your protein and its homologs. If a match is found, the matched regions and statistics will be displayed. The query sequence should be entered using single letter amino acid code.

ID Mapping: Use ID Mapping to see the correspondence between any two identifiers, and therefore facilitate the navigation among databases and analysis programs.

Molecular Weight and Composition: Retrieve the molecular weight of a protein based on its amino acid composition. The calculation notes for the molecular weight of the protein and for each individual amino acid are provided.
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